1 result for (book:deavf1 AND heading:"essay 8 sunday may 23 1982" AND stemmed:rheumatoid)
[... 10 paragraphs ...]
In our ceaseless search for answers to an unending list of personal questions, we discussed the notion that in her own way Jane has described a circle from her childhood: Her parents, Marie and Delmer, were married in Saratoga Springs, a well-known resort town in upper New York State, in 1928. They were divorced in 1931, when Jane was two years old. (Jane didn’t see her father again—he came from a broken home himself—until she was 21.) By the time Jane was three years old, her mother was having serious problems with rheumatoid arthritis. Indeed, the daughter has only one conscious memory of seeing her mother on her feet. All we have are a few photographs Del took of Marie not long after their marriage. They show a beautiful woman wearing a bathing suit, standing on a beach in Florida.
[... 1 paragraph ...]
None of the doctors we talked to would say outright that rheumatoid arthritis is inherited—only that “it seems to run in families,” and that more women than men develop it. Even today we saw a well-known specialist say the same thing on a national television program. Yet except for her mother’s case there’s no history of arthritis in Jane’s family, outside of a “routine” trace of rheumatism in a couple of grandparents. The curious question arises: Why, then, did first Marie and then Jane begin showing their symptoms? (As closely as we can determine, Marie was about 26 years old at their onset. Jane was 35; she’ll be 53 tomorrow.)
[... 1 paragraph ...]
I even think there’s good medical evidence these days for my view of Jane’s “symptoms,” as we’ve called them for many years. In recent years rheumatoid arthritis has been found to be an amazingly complicated disease involving a great number of the body’s immune factors. In the progression of rheumatoid arthritis one’s own immunologic system turns on the body and damages it. A very simplified explanation is that in a process repeated over and over, a variety of defender cells called phagocytic monocytes turn into macrophages, or scavenger cells that, in turn, release enzymes which consume healthy joint tissue. The resulting debris attracts more monocytes, and so on. An inflammatory accumulation of cellular detritus finally destroys the joint’s cartilage and eats away bone.
This isn’t all, however, for experiments have now shown that the brain/mind connection can influence immunity, through stressful conditioning either enhancing its effects or subduing them. Until a very few years ago it was medical dogma that the immune system was entirely independent of any “outside” influence. But recently certain brain chemicals were discovered paired off with cellular chemical “receptors” in the immune system, and researchers expect to find many more of these associations. In physical terms, then, I think it quite possible that in Jane’s case long-term stress, beginning in her early childhood, consistently overstimulated her immune system. Over and over Marie told Jane that she was no good, that the daughter’s birth had caused the mother’s illness. Well before she was 10 years old Jane had developed persistent symptoms of colitis, an inflammation of the large intestine/bowel that is often associated with emotional stress. By her early teens she had an overactive thyroid gland. Marie—and others—told her that she would burn herself out and die before she was 20 years old. Her vision was poor; she required very strong glasses (which she seldom wore). Finally in her mid-30s there came the beginning of rheumatoid arthritis: Jane’s immune system greatly increased its attack upon her body.
[... 5 paragraphs ...]
One of their common creations within the same time scheme was rheumatoid arthritis, of course, for Jane began to show her version of it some eight years before Marie died. That mutual illness obviously became a deeply charged subject for both of them. However, with that fine stubbornness I mentioned in the first essay, Jane never told Marie of her own affliction; since the two no longer saw each other, consciously Marie never knew. Both of us think she did know psychically, though. I even think that mother and daughter shared the same case of arthritis—there weren’t two separate instances of it.
[... 8 paragraphs ...]